The Estense Castle of the Mesola was built in the second sixteenth century by order of the last Duke of Ferrara, Alfonso II, in honor of his third wife, Margherita Gonzaga. Last of the Este "delights", it stands out for its austere and at the same time elegant appearance. At the center of a huge hunting estate, the Castle was surrounded by 12 km long walls, of which nothing remains. However, the service structures are still in a semicircle around the castle, now transformed into shops and restaurants.
The Castle houses the Environmental Education Center, the Library, and is home to temporary exhibitions.